ROS1 and ALK Fusions in Colorectal Cancer, with Evidence of Intra-tumoral Heterogeneity for Molecular Drivers

Activated ALK and ROS1 tyrosine kinases, through gene fusions, has been found in lung adenocarcinomas and are highly sensitive to selective kinase inhibitors. This study aimed at identifying the presence of these rearrangements in human colorectal adenocarcinoma (CRC) specimens using a 4-target, 4-c...

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Main Authors: Aisner, Dara L., Nguyen, Teresa T., Paskulin, Diego D., Le, Anh T., Haney, Jerry, Schulte, Nathan, Chionh, Fiona, Hardingham, Jenny, Mariadason, John, Tebbutt, Niall, Doebele, Robert C., Weickhardt, Andrew J., Varella-Garcia, Marileila
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140177/
https://ncbi.nlm.nih.gov/pubmed/24296758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0479-T
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