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Lamin B1 overexpression increases nuclear rigidity in autosomal dominant leukodystrophy fibroblasts
The architecture and structural mechanics of the cell nucleus are defined by the nuclear lamina, which is formed by A- and B-type lamins. Recently, gene duplication and protein overexpression of lamin B1 (LB1) have been reported in pedigrees with autosomal dominant leukodystrophy (ADLD). However, ho...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Federation of American Societies for Experimental Biology
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4139899/ https://ncbi.nlm.nih.gov/pubmed/24858279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-247635 |
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