Lamin B1 overexpression increases nuclear rigidity in autosomal dominant leukodystrophy fibroblasts

The architecture and structural mechanics of the cell nucleus are defined by the nuclear lamina, which is formed by A- and B-type lamins. Recently, gene duplication and protein overexpression of lamin B1 (LB1) have been reported in pedigrees with autosomal dominant leukodystrophy (ADLD). However, ho...

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Detalhes bibliográficos
Main Authors: Ferrera, Denise, Canale, Claudio, Marotta, Roberto, Mazzaro, Nadia, Gritti, Marta, Mazzanti, Michele, Capellari, Sabina, Cortelli, Pietro, Gasparini, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2014
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139899/
https://ncbi.nlm.nih.gov/pubmed/24858279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-247635
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