Mice overexpressing lamin B1 in oligodendrocytes recapitulate the age-dependent motor signs, but not the early autonomic cardiovascular dysfunction of autosomal-dominant leukodystrophy (ADLD)

Autosomal dominant leukodystrophy (ADLD) is a rare adult-onset demyelinating disease caused by overexpression of lamin B1, a nuclear lamina filament. Early autonomic dysfunction involving the cardiovascular system before progressive somatic motor dysfunction is a striking feature of most cases of AD...

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Detalhes bibliográficos
Publicado no:Exp Neurol
Main Authors: Martire, Viviana Lo, Alvente, Sara, Bastianini, Stefano, Berteotti, Chiara, Bombardi, Cristiano, Calandra-Buonaura, Giovanna, Capellari, Sabina, Cohen, Gary, Cortelli, Pietro, Gasparini, Laura, Padiath, Quasar, Valli, Alice, Zoccoli, Giovanna, Silvani, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809293/
https://ncbi.nlm.nih.gov/pubmed/29262292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2017.12.006
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