Knockdown of estrogen receptor-α induces autophagy and inhibits antiestrogen-mediated unfolded protein response activation, promoting ROS-induced breast cancer cell death

Approximately 70% of all newly diagnosed breast cancers express estrogen receptor (ER)-α. Although inhibiting ER action using targeted therapies such as fulvestrant (ICI) is often effective, later emergence of antiestrogen resistance limits clinical use. We used antiestrogen-sensitive and -resistant...

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Hlavní autoři: Cook, Katherine L., Clarke, Pamela A. G., Parmar, Jignesh, Hu, Rong, Schwartz-Roberts, Jessica L., Abu-Asab, Mones, Wärri, Anni, Baumann, William T., Clarke, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2014
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139896/
https://ncbi.nlm.nih.gov/pubmed/24858277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-247353
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