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Rhes Suppression Enhances Disease Phenotypes in Huntington’s Disease Mice
In Huntington’s disease (HD) mutant HTT is ubiquitously expressed yet the striatum undergoes profound early degeneration. Cell culture studies suggest that a striatal-enriched protein, Rhes, may account for this vulnerability. We investigated the therapeutic potential of silencing Rhes in vivo using...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4139702/ https://ncbi.nlm.nih.gov/pubmed/25062765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-140094 |
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