Preclinical Safety of RNAi-Mediated HTT Suppression in the Rhesus Macaque as a Potential Therapy for Huntington's Disease

To date, a therapy for Huntington's disease (HD), a genetic, neurodegenerative disorder, remains elusive. HD is characterized by cell loss in the basal ganglia, with particular damage to the putamen, an area of the brain responsible for initiating and refining motor movements. Consequently, pat...

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Bibliografiske detaljer
Main Authors: McBride, Jodi L, Pitzer, Mark R, Boudreau, Ryan L, Dufour, Brett, Hobbs, Theodore, Ojeda, Sergio R, Davidson, Beverly L
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242667/
https://ncbi.nlm.nih.gov/pubmed/22031240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.219
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