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Normalizing Glucocorticoid Levels Attenuates Metabolic and Neuropathological Symptoms in the R6/2 Mouse Model of Huntington’s Disease
Huntington’s disease (HD) is a fatal genetic neurological disorder caused by a mutation in the human Huntingtin (HTT) gene. This mutation confers a toxic gain of function of the encoded mutant huntingtin (mHTT) protein, leading to widespread neuropathology including the formation of mHTT-positive in...
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| Udgivet i: | Neurobiol Dis |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6320701/ https://ncbi.nlm.nih.gov/pubmed/30292559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.09.025 |
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