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Normalizing Glucocorticoid Levels Attenuates Metabolic and Neuropathological Symptoms in the R6/2 Mouse Model of Huntington’s Disease

Huntington’s disease (HD) is a fatal genetic neurological disorder caused by a mutation in the human Huntingtin (HTT) gene. This mutation confers a toxic gain of function of the encoded mutant huntingtin (mHTT) protein, leading to widespread neuropathology including the formation of mHTT-positive in...

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Bibliografski detalji
Izdano u:Neurobiol Dis
Glavni autori: Dufour, Brett D., McBride, Jodi L.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320701/
https://ncbi.nlm.nih.gov/pubmed/30292559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.09.025
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