Preclinical Safety of RNAi-Mediated HTT Suppression in the Rhesus Macaque as a Potential Therapy for Huntington's Disease

To date, a therapy for Huntington's disease (HD), a genetic, neurodegenerative disorder, remains elusive. HD is characterized by cell loss in the basal ganglia, with particular damage to the putamen, an area of the brain responsible for initiating and refining motor movements. Consequently, pat...

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Detalhes bibliográficos
Main Authors: McBride, Jodi L, Pitzer, Mark R, Boudreau, Ryan L, Dufour, Brett, Hobbs, Theodore, Ojeda, Sergio R, Davidson, Beverly L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242667/
https://ncbi.nlm.nih.gov/pubmed/22031240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.219
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