Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.

To investigate the role of intronic immunoglobulin heavy chain (IgH) enhancer (E mu) in generating accessibility of the JH locus for VDJ recombination, we generated ES cells in which E mu or its flanking sequences were mutated by replacement with or insertion of an expressed neor gene. Heterozygous...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:EMBO J
Egile Nagusiak: Chen, J, Young, F, Bottaro, A, Stewart, V, Smith, R K, Alt, F W
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 1993
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413901/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8223473/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb06152.x
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