Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.

To investigate the role of intronic immunoglobulin heavy chain (IgH) enhancer (E mu) in generating accessibility of the JH locus for VDJ recombination, we generated ES cells in which E mu or its flanking sequences were mutated by replacement with or insertion of an expressed neor gene. Heterozygous...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Chen, J, Young, F, Bottaro, A, Stewart, V, Smith, R K, Alt, F W
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 1993
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413901/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8223473/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb06152.x
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