Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.

To investigate the role of intronic immunoglobulin heavy chain (IgH) enhancer (E mu) in generating accessibility of the JH locus for VDJ recombination, we generated ES cells in which E mu or its flanking sequences were mutated by replacement with or insertion of an expressed neor gene. Heterozygous...

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Dades bibliogràfiques

Publicat a:	EMBO J
Autors principals:	Chen, J, Young, F, Bottaro, A, Stewart, V, Smith, R K, Alt, F W
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 1993
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413901/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8223473/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb06152.x
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