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Mutations in the conserved loop of human U5 snRNA generate use of novel cryptic 5' splice sites in vivo.

We have analyzed base pairing interactions between the U5 snRNA and 5' exon sequences during pre-mRNA splicing in a mammalian in vivo system. We constructed synthetic U5 genes with mutations that alter four bases (C3, U4, U5 and U6) within the invariant 9 nt U5 sequence GCCUUUUAC; transient tra...

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Bibliografiske detaljer
Main Authors: Cortes, J J, Sontheimer, E J, Seiwert, S D, Steitz, J A
Format: Artigo
Sprog:Inglês
Udgivet: 1993
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC413781/
https://ncbi.nlm.nih.gov/pubmed/8262061
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