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Proximity of conserved U6 and U2 snRNA elements to the 5′ splice site region in activated spliceosomes

Major structural changes occur in the spliceosome during its catalytic activation, which immediately precedes the splicing of pre-mRNA. Whereas changes in snRNA conformation are well documented at the level of secondary RNA–RNA interactions, little is known about the tertiary structure of this RNA–R...

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Bibliographic Details
Main Authors: Rhode, Britta M, Hartmuth, Klaus, Westhof, Eric, Lührmann, Reinhard
Format: Artigo
Language:Inglês
Published: 2006
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1478171/
https://ncbi.nlm.nih.gov/pubmed/16688215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601134
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