Development of a novel cellular model of Alzheimer’s disease utilizing neurosphere cultures derived from B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J embryonic mouse brain

Increased production, oligomerization and aggregation of amyloid-β (Aβ) peptides are hallmark pathologies of Alzheimer’s disease (AD). Expressing familial AD mutations (amyloid precursor protein and/or presenilins mutations), the Aβ-pathologies of AD has been recapitulated in animal models of AD. Ve...

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Bibliografische gegevens
Hoofdauteurs: Ghate, Pankaj S, Sidhar, Himakshi, Carlson, George A, Giri, Ranjit K
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer International Publishing 2014
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137416/
https://ncbi.nlm.nih.gov/pubmed/25140287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2193-1801-3-161
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