Prion infection of mouse neurospheres

Only a few cell lines have been infected with prions, offering limited genetic diversity and sensitivity to several strains. Here we report that cultured neurospheres expressing cellular prion protein (PrP(C)) can be infected with prions. Neurosphere lines isolated from the brains of mice at embryon...

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Bibliografiske detaljer
Main Authors: Giri, Ranjit K., Young, Rebecca, Pitstick, Rose, DeArmond, Stephen J., Prusiner, Stanley B., Carlson, George A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1533787/
https://ncbi.nlm.nih.gov/pubmed/16495413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510902103
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