Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase

[Image: see text] The Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) is an oncogenic phosphatase associated with various kinds of leukemia and solid tumors. Thus, there is substantial interest in developing SHP2 inhibitors as potential anticancer and antileukemia agents. Usin...

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Détails bibliographiques
Auteurs principaux: Zeng, Li-Fan, Zhang, Ruo-Yu, Yu, Zhi-Hong, Li, Sijiu, Wu, Li, Gunawan, Andrea M., Lane, Brandon S., Mali, Raghuveer S., Li, Xingjun, Chan, Rebecca J., Kapur, Reuben, Wells, Clark D., Zhang, Zhong-Yin
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2014
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136714/
https://ncbi.nlm.nih.gov/pubmed/25003231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5006176
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