KCNJ10 determines the expression of the apical Na-Cl cotransporter (NCC) in the early distal convoluted tubule (DCT1)

The renal phenotype induced by loss-of-function mutations of inwardly rectifying potassium channel (Kir), Kcnj10 (Kir4.1), includes salt wasting, hypomagnesemia, metabolic alkalosis and hypokalemia. However, the mechanism by which Kir.4.1 mutations cause the tubulopathy is not completely understood....

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Zhang, Chengbiao, Wang, Lijun, Zhang, Junhui, Su, Xiao-Tong, Lin, Dao-Hong, Scholl, Ute I., Giebisch, Gerhard, Lifton, Richard P., Wang, Wen-Hui
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2014
Θέματα:
Biological Sciences
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136599/
https://ncbi.nlm.nih.gov/pubmed/25071208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411705111
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