KCNJ10 determines the expression of the apical Na-Cl cotransporter (NCC) in the early distal convoluted tubule (DCT1)

The renal phenotype induced by loss-of-function mutations of inwardly rectifying potassium channel (Kir), Kcnj10 (Kir4.1), includes salt wasting, hypomagnesemia, metabolic alkalosis and hypokalemia. However, the mechanism by which Kir.4.1 mutations cause the tubulopathy is not completely understood....

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Detalhes bibliográficos
Main Authors: Zhang, Chengbiao, Wang, Lijun, Zhang, Junhui, Su, Xiao-Tong, Lin, Dao-Hong, Scholl, Ute I., Giebisch, Gerhard, Lifton, Richard P., Wang, Wen-Hui
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136599/
https://ncbi.nlm.nih.gov/pubmed/25071208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411705111
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