KCNJ10 determines the expression of the apical Na-Cl cotransporter (NCC) in the early distal convoluted tubule (DCT1)

The renal phenotype induced by loss-of-function mutations of inwardly rectifying potassium channel (Kir), Kcnj10 (Kir4.1), includes salt wasting, hypomagnesemia, metabolic alkalosis and hypokalemia. However, the mechanism by which Kir.4.1 mutations cause the tubulopathy is not completely understood....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhang, Chengbiao, Wang, Lijun, Zhang, Junhui, Su, Xiao-Tong, Lin, Dao-Hong, Scholl, Ute I., Giebisch, Gerhard, Lifton, Richard P., Wang, Wen-Hui
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2014
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136599/
https://ncbi.nlm.nih.gov/pubmed/25071208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411705111
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