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Mechanism of Resistance to S138A Substituted Enfuvirtide and its Application to Peptide Design

T-20 (enfuvirtide) resistance is caused by the N43D primary resistance mutation at its presumed binding site at the N-terminal heptad repeat (N-HR) of gp41, accompanied by the S138A secondary mutation at the C-terminal HR of gp41 (C-HR). We have discovered that modifying T-20 to include S138A (T-20(...

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Podrobná bibliografie
Hlavní autoři:	Izumi, Kazuki, Kawaji, Kumi, Miyamoto, Fusasko, Shimane, Kazuki, Shimura, Kazuya, Sakagami, Yasuko, Hattori, Toshio, Watanabe, Kentaro, Oishi, Shinya, Fujii, Nobutaka, Matsuoka, Masao, Kaku, Mitsuo, Sarafianos, Stefan G., Kodama, Eiichi N.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	2013
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4136414/ https://ncbi.nlm.nih.gov/pubmed/23357451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2013.01.015
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Mechanism of Resistance to S138A Substituted Enfuvirtide and its Application to Peptide Design

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