STAT4 Deficiency Fails To Induce Lung Th2 or Th17 Immunity following Primary or Secondary Respiratory Syncytial Virus (RSV) Challenge but Enhances the Lung RSV-Specific CD8(+) T Cell Immune Response to Secondary Challenge

Immune-mediated lung injury is a hallmark of lower respiratory tract illness caused by respiratory syncytial virus (RSV). STAT4 plays a critical role in CD4(+) Th1 lineage differentiation and gamma interferon (IFN-γ) protein expression by CD4(+) T cells. As CD4(+) Th1 differentiation is associated w...

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Bibliographic Details
Main Authors: Dulek, Daniel E., Newcomb, Dawn C., Toki, Shinji, Goliniewska, Kasia, Cephus, Jacqueline, Reiss, Sara, Bates, John T., Crowe, James E., Boyd, Kelli L., Moore, Martin L., Zhou, Weisong, Peebles, R. Stokes
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136353/
https://ncbi.nlm.nih.gov/pubmed/24920804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03299-13
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