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STAT4 Deficiency Fails To Induce Lung Th2 or Th17 Immunity following Primary or Secondary Respiratory Syncytial Virus (RSV) Challenge but Enhances the Lung RSV-Specific CD8(+) T Cell Immune Response to Secondary Challenge

Immune-mediated lung injury is a hallmark of lower respiratory tract illness caused by respiratory syncytial virus (RSV). STAT4 plays a critical role in CD4(+) Th1 lineage differentiation and gamma interferon (IFN-γ) protein expression by CD4(+) T cells. As CD4(+) Th1 differentiation is associated w...

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書誌詳細
主要な著者: Dulek, Daniel E., Newcomb, Dawn C., Toki, Shinji, Goliniewska, Kasia, Cephus, Jacqueline, Reiss, Sara, Bates, John T., Crowe, James E., Boyd, Kelli L., Moore, Martin L., Zhou, Weisong, Peebles, R. Stokes
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136353/
https://ncbi.nlm.nih.gov/pubmed/24920804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03299-13
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