Protein Binding of Rifapentine and Its 25-Desacetyl Metabolite in Patients with Pulmonary Tuberculosis

Rifapentine is highly protein bound in blood, but the free, unbound drug is the microbiologically active fraction. In this exploratory study, we characterized the free plasma fraction of rifapentine in 41 patients with tuberculosis. We found a lower total rifapentine concentration but significantly...

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Xehetasun bibliografikoak
Egile Nagusiak: Egelund, Eric F., Weiner, Marc, Singh, Rajendra P., Prihoda, Thomas J., Gelfond, Jonathon A. L., Derendorf, Hartmut, Mac Kenzie, William R., Peloquin, Charles A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2014
Gaiak:
Pharmacology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136068/
https://ncbi.nlm.nih.gov/pubmed/24841270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01730-13
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