Protein Binding of Rifapentine and Its 25-Desacetyl Metabolite in Patients with Pulmonary Tuberculosis

Rifapentine is highly protein bound in blood, but the free, unbound drug is the microbiologically active fraction. In this exploratory study, we characterized the free plasma fraction of rifapentine in 41 patients with tuberculosis. We found a lower total rifapentine concentration but significantly...

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Main Authors: Egelund, Eric F., Weiner, Marc, Singh, Rajendra P., Prihoda, Thomas J., Gelfond, Jonathon A. L., Derendorf, Hartmut, Mac Kenzie, William R., Peloquin, Charles A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136068/
https://ncbi.nlm.nih.gov/pubmed/24841270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01730-13
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