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Role of the C Terminus of Lassa Virus L Protein in Viral mRNA Synthesis

The N terminus of arenavirus L protein contains an endonuclease presumably involved in “cap snatching.” Here, we employed the Lassa virus replicon system to map other L protein sites that might be involved in this mechanism. Residues Phe-1979, Arg-2018, Phe-2071, Asp-2106, Trp-2173, Tyr-2179, Arg-22...

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Detalhes bibliográficos
Main Authors: Lehmann, Maria, Pahlmann, Meike, Jérôme, Hanna, Busch, Carola, Lelke, Michaela, Günther, Stephan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135956/
https://ncbi.nlm.nih.gov/pubmed/24829349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00652-14
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