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Mutational Evidence for a Structural Model of the Lassa Virus RNA Polymerase Domain and Identification of Two Residues, Gly1394 and Asp1395, That Are Critical for Transcription but Not Replication of the Genome

The RNA-dependent RNA polymerase (RdRp) of arenaviruses is an integral part of the L protein, a 200-kDa multifunctional and multidomain protein. In view of the paucity of structural data, we recently proposed a model for the RdRp domain of arenaviruses based on the folding of RdRps of plus-strand vi...

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מידע ביבליוגרפי
Main Authors: Hass, Meike, Lelke, Michaela, Busch, Carola, Becker-Ziaja, Beate, Günther, Stephan
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566270/
https://ncbi.nlm.nih.gov/pubmed/18667512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00220-08
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