The N Terminus and C Terminus of Herpes Simplex Virus 1 ICP4 Cooperate To Activate Viral Gene Expression

Infected cell polypeptide 4 (ICP4) activates transcription from most viral promoters. Two transactivation domains, one N-terminal and one C terminal, are largely responsible for the activation functions of ICP4. A mutant ICP4 molecule lacking the C-terminal activation domain (n208) efficiently activ...

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Hauptverfasser: Wagner, Lauren M., Lester, Jonathan T., Sivrich, Frances L., DeLuca, Neal A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Genome Replication and Regulation of Viral Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393571/
https://ncbi.nlm.nih.gov/pubmed/22496239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00651-12
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