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Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex.

HIV-1 integrase protein possesses the 3' processing and DNA strand transfer activities that are required to integrate HIV DNA into a host chromosome. The N-, C-terminal and core domains of integrase are necessary for both activities in vitro. We find that certain pairs of mutant integrase prote...

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Bibliografski detalji
Glavni autori: Engelman, A, Bushman, F D, Craigie, R
Format: Artigo
Jezik:Inglês
Izdano: 1993
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC413594/
https://ncbi.nlm.nih.gov/pubmed/8344264
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