Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex.

HIV-1 integrase protein possesses the 3' processing and DNA strand transfer activities that are required to integrate HIV DNA into a host chromosome. The N-, C-terminal and core domains of integrase are necessary for both activities in vitro. We find that certain pairs of mutant integrase prote...

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Bibliographic Details
Published in:EMBO J
Main Authors: Engelman, A, Bushman, F D, Craigie, R
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1993
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413594/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8344264/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05996.x
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