Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein

Retroviral integrase, an essential enzyme for replication of human immunodeficiency virus type-1 (HIV-1) and other retroviruses, contains three structurally distinct domains, an N-terminal domain, the catalytic core and a C-terminal domain. To elucidate their spatial arrangement, we have solved the...

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Pubblicato in:	EMBO J
Autori principali:	Wang, Jian-Yong, Ling, Hong, Yang, Wei, Craigie, Robert
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125787/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11743009/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.24.7333
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