Chemically Modified Peptides Based on the Membrane-Proximal External Region of the HIV-1 Envelope Induce High-Titer, Epitope-Specific Nonneutralizing Antibodies in Rabbits

Broadly neutralizing monoclonal antibodies (bNAbs) 2F5 and 4E10 bind to the membrane proximal external region (MPER) of gp41 and also cross-react with phospholipids. In this study, we investigated if chemical modifications on the MPER adjacent to 2F5 and 4E10 epitopes using mimetics of inflammation-...

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Hlavní autoři: Venditto, Vincent J., Wieczorek, Lindsay, Molnar, Sebastian, Teque, Fernando, Landucci, Gary, Watson, Douglas S., Forthal, Donald, Polonis, Victoria R., Levy, Jay A., Szoka, Francis C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135905/
https://ncbi.nlm.nih.gov/pubmed/24872518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00320-14
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