Activity of Praziquantel Enantiomers and Main Metabolites against Schistosoma mansoni

A racemic mixture of R and S enantiomers of praziquantel (PZQ) is currently the treatment of choice for schistosomiasis. Though the S enantiomer and the metabolites are presumed to contribute only a little to the activity of the drug, in-depth side-by-side studies are lacking. The aim of this study...

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Autores principales: Meister, Isabel, Ingram-Sieber, Katrin, Cowan, Noemi, Todd, Matthew, Robertson, Murray N., Meli, Claudia, Patra, Malay, Gasser, Gilles, Keiser, Jennifer
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135865/
https://ncbi.nlm.nih.gov/pubmed/24982093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02741-14
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