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Disposition of Mefloquine and Enpiroline Is Highly Influenced by a Chronic Schistosoma mansoni Infection

Chronic Schistosoma mansoni infections lead to severe tissue destruction of the gut wall and liver and can influence drug disposition. This study aimed to investigate the impact of a chronic S. mansoni infection on the pharmacokinetic (PK) parameters of two promising antischistosomal lead candidates...

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Detalhes bibliográficos
Main Authors: Ingram, Katrin, Duthaler, Urs, Vargas, Mireille, Ellis, William, Keiser, Jennifer
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754359/
https://ncbi.nlm.nih.gov/pubmed/23836173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01129-13
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