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In vitro and in vivo activity of R- and S- praziquantel enantiomers and the main human metabolite trans-4-hydroxy-praziquantel against Schistosoma haematobium

BACKGROUND: Praziquantel (PZQ) is the mainstay of schistosomiasis control and has been successfully used for decades. However, its mechanism of action is not fully understood. While the majority of studies have been conducted on Schistosoma mansoni, it is not known which enantiomer, R- or S-praziqua...

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Bibliografske podrobnosti
izdano v:Parasit Vectors
Main Authors: Kovač, Jana, Vargas, Mireille, Keiser, Jennifer
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540299/
https://ncbi.nlm.nih.gov/pubmed/28764732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13071-017-2293-3
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