Caveolin-1 Is Required for Kinase Suppressor of Ras 1 (KSR1)-Mediated Extracellular Signal-Regulated Kinase 1/2 Activation, H-Ras(V12)-Induced Senescence, and Transformation

The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates the activation of the Raf/MEK/extracellular signal-regulated kinase (ERK) signal transduction pathway. KSR1 disruption in mouse embryo fibroblasts (MEFs) abrogates growth factor-induced ERK activation, H-Ras(V12)-induced replicative...

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Bibliographic Details
Main Authors: Kortum, Robert L., Fernandez, Mario R., Costanzo-Garvey, Diane L., Johnson, Heidi J., Fisher, Kurt W., Volle, Deanna J., Lewis, Robert E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135613/
https://ncbi.nlm.nih.gov/pubmed/25002533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01633-13
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