Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins

In mammals, there are four NOTCH receptors and five Delta-Jagged-type ligands regulating many aspects of embryonic development and adult tissue homeostasis. NOTCH proteins are type I transmembrane receptors that interact with ligands on adjacent cells and are activated by regulated intramembrane pro...

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Main Authors: Groot, Arjan J., Habets, Roger, Yahyanejad, Sanaz, Hodin, Caroline M., Reiss, Karina, Saftig, Paul, Theys, Jan, Vooijs, Marc
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135574/
https://ncbi.nlm.nih.gov/pubmed/24842903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00206-14
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