MEN1-tumorigenesis in the pituitary and pancreatic islet requires Cdk4 but not Cdk2

Recent studies suggest that physiological and tumorigenic proliferation of mammalian cells is controlled by multiple cyclin-dependent kinases (CDKs) largely in tissue-specific manners. We and others previously demonstrated that adult mice deficient for the D-cyclin-dependent kinase CDK4 (Cdk4(−/−) m...

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Autores principales: Gillam, Mary P., Nimbalkar, Dipali, Sun, Limin, Christov, Konstantin, Ray, Dipankar, Kaldis, Philipp, Liu, Xianpeng, Kiyokawa, Hiroaki
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135037/
https://ncbi.nlm.nih.gov/pubmed/24531709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.3
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