Characterization and assessment of the sensitivity and resistance of a newly established human gastrointestinal stromal tumour xenograft model to treatment with tyrosine kinase inhibitors

BACKGROUND: Acquired resistance to tyrosine kinase inhibitors (TKIs) in gastrointestinal stromal tumours (GISTs) is most commonly caused by secondary KIT or PDGFRA mutations. In this study we characterize a newly established GIST xenograft model, UZLX-GIST9, and evaluate the in vivo response of the...

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Hoofdauteurs: Van Looy, Thomas, Gebreyohannes, Yemarshet Kelemework, Wozniak, Agnieszka, Cornillie, Jasmien, Wellens, Jasmien, Li, Haifu, Vanleeuw, Ulla, Floris, Giuseppe, Debiec-Rychter, Maria, Sciot, Raf, Schöffski, Patrick
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2014
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134663/
https://ncbi.nlm.nih.gov/pubmed/25132955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-3329-4-10
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