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The DNA-Binding Domain Mediates both Nuclear and Cytosolic Functions of p53
Under conditions of genotoxic stress, human p53 activates the apoptotic effectors BAX or BAK, resulting in mitochondrial outer membrane permeabilization and apoptosis. Anti-apoptotic BCL-2 family member BCL-xL opposes this activity by sequestering cytosolic p53 via association with its DNA-binding d...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4134560/ https://ncbi.nlm.nih.gov/pubmed/24814347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2829 |
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