PUMA Binding Induces Partial Unfolding within BCL-xL to Disrupt p53 Binding and Promote Apoptosis

Following DNA damage, nuclear p53 induces the expression of PUMA, a BH3-only protein that binds and inhibits the anti-apoptotic BCL-2 repertoire, including BCL-xL. PUMA, unique amongst BH3-only proteins, disrupts the interaction between cytosolic p53 and BCL-xL, allowing p53 to promote apoptosis via...

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Main Authors: Follis, Ariele Viacava, Chipuk, Jerry E., Fisher, John C., Yun, Mi-Kyung, Grace, Christy R., Nourse, Amanda, Baran, Katherine, Ou, Li, Min, Lie, White, Stephen W., Green, Douglas R., Kriwacki, Richard W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683295/
https://ncbi.nlm.nih.gov/pubmed/23340338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1166
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