Reactivation of developmentally silenced globin genes by forced chromatin looping

Distal enhancers commonly contact target promoters via chromatin looping. In erythroid cells, the locus control region (LCR) contacts β-type globin genes in a developmental stage-specific manner to stimulate transcription. Previously, we induced LCR-promoter looping by tethering the self-association...

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Hauptverfasser: Deng, Wulan, Rupon, Jeremy W., Krivega, Ivan, Breda, Laura, Motta, Irene, Jahn, Kristen S., Reik, Andreas, Gregory, Philip D., Rivella, Stefano, Dean, Ann, Blobel, Gerd A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134511/
https://ncbi.nlm.nih.gov/pubmed/25126789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.05.050
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