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Left-right asymmetry in the level of active Nodal protein produced in the node is translated into left-right asymmetry in the lateral plate of mouse embryos

Left-right (L-R) asymmetry in the mouse embryo is generated in the node and is dependent on cilia-driven fluid flow, but how the initial asymmetry is transmitted from the node to the lateral plate has remained unknown. We have now identified a transcriptional enhancer (ANE) in the human LEFTY1 gene...

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Autors principals: Kawasumi, Aiko, Nakamura, Tetsuya, Iwai, Naomi, Yashiro, Kenta, Saijoh, Yukio, Belo, Jose Antonio, Shiratori, Hidetaka, Hamada, Hiroshi
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134472/
https://ncbi.nlm.nih.gov/pubmed/21419113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2011.03.009
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