Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2

Unidirectional fluid flow plays an essential role in the breaking of left-right (L-R) symmetry in mouse embryos, but it has remained unclear how the flow is sensed by the embryo. We report that the Ca(2+) channel Pkd2 is required specifically in the peri-nodal crown cells for sensing the nodal flow....

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Main Authors: Yoshiba, Satoko, Shiratori, Hidetaka, Kuo, Ivana Y., Kawasumi, Aiko, Shinohara, Kyosuke, Nonaka, Shigenori, Asai, Yasuko, Sasaki, Genta, Belo, Jose Antonio, Sasaki, Hiroshi, Nakai, Junichi, Dworniczak, Bernd, Ehrlich, Barbara E., Pennekamp, Petra, Hamada, Hiroshi
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711115/
https://ncbi.nlm.nih.gov/pubmed/22983710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1222538
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