Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm

Axonemal dynein complexes are preassembled in the cytoplasm before their transport to cilia, but the mechanism of this process remains unclear. We now show that mice lacking Pih1d3, a PIH1 domain–containing protein, develop normally but manifest male sterility. Pih1d3(−/−) sperm were immotile and fr...

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Bibliografski detalji
Glavni autori: Dong, Fenglan, Shinohara, Kyosuke, Botilde, Yanick, Nabeshima, Ryo, Asai, Yasuko, Fukumoto, Akemi, Hasegawa, Toshiaki, Matsuo, Moe, Takeda, Hiroyuki, Shiratori, Hidetaka, Nakamura, Tetsuya, Hamada, Hiroshi
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2014
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897177/
https://ncbi.nlm.nih.gov/pubmed/24421334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201304076
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