Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm

Axonemal dynein complexes are preassembled in the cytoplasm before their transport to cilia, but the mechanism of this process remains unclear. We now show that mice lacking Pih1d3, a PIH1 domain–containing protein, develop normally but manifest male sterility. Pih1d3(−/−) sperm were immotile and fr...

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Bibliographische Detailangaben
Hauptverfasser: Dong, Fenglan, Shinohara, Kyosuke, Botilde, Yanick, Nabeshima, Ryo, Asai, Yasuko, Fukumoto, Akemi, Hasegawa, Toshiaki, Matsuo, Moe, Takeda, Hiroyuki, Shiratori, Hidetaka, Nakamura, Tetsuya, Hamada, Hiroshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2014
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897177/
https://ncbi.nlm.nih.gov/pubmed/24421334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201304076
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