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Co-targeting c-Met and COX-2 leads to enhanced inhibition of lung tumorigenesis in a murine model with heightened airway HGF
BACKGROUND: The hepatocyte growth factor (HGF)/c-Met pathway is often dysregulated in non-small cell lung cancer (NSCLC). HGF activation of c-Met induces cyclooxygenase-2 (COX-2), resulting in downstream stimulation by PGE2 of additional pathways. Targeting both c-Met and COX-2 might lead to enhance...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4134355/ https://ncbi.nlm.nih.gov/pubmed/25057941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0000000000000245 |
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