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Targeting of Both the c-Met and EGFR Pathways Results in Additive Inhibition of Lung Tumorigenesis in Transgenic Mice

EGFR and c-Met are both overexpressed in lung cancer and initiate similar downstream signaling, which may be redundant. To determine how frequently ligands that initiate signaling of both pathways are found in lung cancer, we analyzed serum for hepatocyte growth factor (HGF), transforming growth fac...

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Detalhes bibliográficos
Main Authors: Stabile, Laura P., Rothstein, Mary E., Keohavong, Phouthone, Lenzner, Diana, Land, Stephanie R., Gaither-Davis, Autumn L., Kim, K. Jin, Kaminski, Naftali, Siegfried, Jill M.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049550/
https://ncbi.nlm.nih.gov/pubmed/21390244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers2042153
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