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Dual blockade of EGFR and c-Met abrogates redundant signaling and proliferation in head and neck carcinoma cells

PURPOSE: Head and neck squamous cell carcinoma (HNSCC) is usually fatal, and innovative approaches targeting growth pathways are necessary to effectively treat this disease. Both the epidermal growth factor receptor (EGFR) and the hepatocyte growth factor (HGF)/c-Met pathways are overexpressed in HN...

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Detalhes bibliográficos
Main Authors: Xu, Hai, Stabile, Laura P., Gubish, Christopher T., Gooding, William E., Grandis, Jennifer R., Siegfried, Jill M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138116/
https://ncbi.nlm.nih.gov/pubmed/21622718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-3339
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