Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation

The ionotropic glutamate receptors (NMDAR) are composed of large complexes of multi-protein subunits creating ion channels in the cell plasma membranes that allow for influx or efflux of mono- or divalent cations (e.g., Ca(2+)) important for synaptic transmissions, cellular migration and survival. R...

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Main Authors: Prickett, Todd D., Zerlanko, Brad J., Hill, Victoria K., Gartner, Jared J., Qutob, Nouar, Jiang, Jiji, Simaan, May, Wunderlich, John, Gutkind, J. Silvio, Rosenberg, Steven A., Samuels, Yardena
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134353/
https://ncbi.nlm.nih.gov/pubmed/24739903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2014.190
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