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Mutational and Functional Analysis of the Tumor-Suppressor PTPRD in Human Melanoma

Protein tyrosine phosphatases (PTPs) tightly regulate tyrosine phosphorylation essential for cell growth, adhesion, migration, and survival. We performed a mutational analysis of the PTP gene family in cutaneous metastatic melanoma and identified 23 phosphatase genes harboring somatic mutations. Amo...

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Detalhes bibliográficos
Publicado no:Hum Mutat
Main Authors: Walia, Vijay, Prickett, Todd D., Kim, Jung-Sik, Gartner, Jared J., Lin, Jimmy C., Zhou, Ming, Rosenberg, Steven A., Elble, Randolph C., Solomon, David A., Waldman, Todd, Samuels, Yardena
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394620/
https://ncbi.nlm.nih.gov/pubmed/25113440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.22630
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